And for a great, in-depth interview with Zwigoff about the making of Crumb, I highly recommend this site, which includes these bits:
There was certainly times when I was following him around with a camera where he would get to the point where he was running out of patience for it. He would turn to me and say, “If you were not my best friend, I would be so out of here.”
Robert always thought [Crumb] would just be shown on my living room wall. And when it wasn’t and when it sort of caught on and started being released to theaters theatrically and getting all these favorable reviews in all the magazines and newspapers, it really had an alarming effect on his life where he would start to get recognized on the street and journalists were showing up on his doorstep to interview him. And his life as he knew it was changing.